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What is sodium carboxymethyl cellulose?

2021-01-22

What is sodium carboxymethyl cellulose


Sodium carboxymethyl cellulose

sodium carboxymethyl cellulose
 

Carboxymethyl cellulose sodium (also known as carboxymethyl cellulose sodium salt, carboxymethyl cellulose sodium, CMC, Carboxymethyl, CelluloseSodium, SodiumsaltofCaboxyMethylCelulose) is the most widely used and widely used type of methyl cellulose in today's society.

Commonly known as CMC-Na, is a glucose water glass transition temperature of 100 ~ 2000 methyl cellulose compounds, relative molecular mass 242.16. white methyl cellulose or granular powder form. Odorless, odorless, water absorbent, insoluble in organic solvents.

Chemical structure formula:C6H7(OH)2OCH2COONa Chemical formula:C8H11O5Na

Scope of application.

As a tackifier in the food industry, as a pharmaceutical medium in the pharmaceutical industry, as a binder and anti-re-settling agent in the daily chemical industry. It is used as desizing agent and maintenance colloidal solution of garment printing paste in industrial production of printing and dyeing factory, etc. In petrochemical equipment, it can be used as a component of fracturing fluid in oil recovery plants.

Basic properties.

This product is the acetate of methyl cellulose carboxymethyl ether, anionic cellulose ether, white or milk white methyl cellulose powder or granules, relative density 0.5-0.7g/cm3, basically odorless, odorless, with water absorption. Easy to disperse in water into a transparent ribbon-like aqueous solution, insoluble in alcohol and other organic chemical soluble enzymes. 1% aqueous solution pH 6.5-8.5, when pH>10 or <5, the viscosity of the pulp is obviously reduced, the best characteristics at pH=7. Smooth to heat, the viscosity rises rapidly below 20, the transformation is slower at 45, and the long-term heating above 80can make its colloidal solution transitive and the viscosity and characteristics decrease significantly. Soluble in strong electrolytes, aqueous solution is fully transparent; smooth in alkaline solution, easy to hydrolysis reaction when it meets acid, precipitation will appear when PH value is 2-3, and precipitation will also react when it meets multivalent metal salt.


Operation method.

Mix CMC with water immediately and configure it into a viscous adhesive and then set aside. When equipped with CMC paste adhesive, first add a certain amount of neat water to the mixing master cylinder containing mixing equipment, and in the condition of opening the mixing equipment, splash CMC into the mixing master cylinder slowly and evenly, and keep mixing so that CMC and water are thoroughly combined and CMC can be sufficiently melted. When melting CMC, it is often necessary to spread it evenly and mix it continuously, in order to "better avoid the problem of clumping and agglomeration when CMC meets with water and reduce the amount of CMC melting" and to improve the melting rate of CMC. Generally speaking, the mixing time is much shorter than the time required for the complete melting of CMC, and the time required for both depends on the details.

The basis for defining the mixing time is.

When the CMC in the water dispersion, there is no significant large group of small pieces of objects, then you can stop mixing, so that CMC and water in the case of static infiltration, combined with each other.

The basis for the complete melting of CMC is as follows.

CMC and water thoroughly bonded, there will be no solid-liquid separation between the two; mixing and paste is uniform, the surface layer is flat and smooth; mixing and paste color close to no color full transparency, paste in the absence of particulate matter. From the time CMC is put into the mixing tank and water mixing, to the CMC completely melted, the time required in the middle of 10 ~ 20 hours.

Quality.

The key index values to evaluate the quality of CMC are substitution degree (DS) and purity. Generally DS is different, the characteristics of CMC are also different; the degree of substitution expands, the solubility increases, and the clarity and reliability of the aqueous solution is higher. It is reported that the clarity and transparency of CMC is most desirable when the degree of substitution is 0.7 to 1.2, and its solution viscosity is maximum at pH 6 to 9. In order to ensure its quality, in addition to the selection of the etherizing agent, must also take into account some elements that endanger the degree of substitution and purity, such as the amount of alkali and etherizing agent used in the middle of the correlation, etherification time, management system moisture content, temperature, pH, substance concentration and acidity, etc..

Common problems

This product is contraindicated with strong alkali, strong acid, heavy metal ions (such as aluminum, zinc, mercury, silver, iron, etc.).

The allowable intake of this product is 0~25mg/kg-d.

National standard specification

GB/T12028-2006 Sodium carboxymethyl cellulose for detergents 684KB

GB1904-2005 Sodium carboxymethyl cellulose for food additive342KB

SY5093-92 Carboxymethyl Cellulose Acetate (CMC) for Drilling Fluids835KB

GB1904-2005 edible additive sodium carboxymethyl cellulose 1579KB

GB1904-1989 edible additive sodium carboxymethyl cellulose 213KB

QB/T2318-2007 Sodium carboxymethyl cellulose for toothpaste625KB

 

Does sodium carboxymethyl cellulose have toxic side effects on human body?

Sodium carboxymethyl cellulose is chemically inert and physiologically inert, does not participate in physiological metabolism; the main raw materials for CMC production are refined cotton, chloroacetic acid and NaOH, although chloroacetic acid is highly toxic, but the alkali in the reaction is in excess, there will be no residue, and the production process of high concentration of alcohol as a solvent and high temperature treatment will not have microbial contamination; therefore, it is not harmful to human body. It is widely used in food, toothpaste, paper making, oil field, printing and dyeing, washing and coating industries.

 

Sodium carboxymethyl cellulose is very low in toxicity and is relatively safe. See: FAO and WHO have approved the use of pure CMC in food, it is approved after very strict biological and toxicological studies and tests, the international standard safe intake (ADI) is 25mg/(kg-d), which is about 1.5 g/d per person.

 

The following is the Swiss albino mice experiment of sodium carboxymethyl cellulose.

Food grade carboxymethyl cellulose was prepared from corn husk agricultural waste and evaluated for subchronic oral toxicity in Swiss albino mice. Forty male mice were divided into four groups and fed a diet of 0 (control)-10% CMC for 3 months. The daily oral dose was 5-20 mg/g body weight of mice/day. Animal care and handling was in accordance with internationally accepted standard guidelines. Hematological and biochemical parameters were monitored during this period. At the end of the study, histopathological changes in tissues and organs were studied. Repeated dose oral toxicity studies were conducted according to OECD guideline 408. The results showed no treatment-related abnormalities in hematological and biochemical parameters. However, water intake, urine volume and urinary sodium excretion increased with increasing doses of CMC. Weekly body weights were not significantly different between control and mice treated with different doses of CMC. No abnormalities were found in the histopathology of liver, heart, lung and kidney of the treated mice. This indicated that the prepared CMC had no toxic effects on cellular structures at different doses and supported the safe use of CMC as a food additive and pharmaceutical excipient.


Sodium carboxymethyl cellulose

 Carboxymethyl cellulose sodium (also known as carboxymethyl cellulose sodium salt, carboxymethyl cellulose sodium, CMC, Carboxymethyl, CelluloseSodium, SodiumsaltofCaboxyMethylCelulose) is the most widely used and widely used type of methylcellulose in today's society.

CMC-Na is a glucose water glass transition temperature of 100 ~ 2000 methylcellulose compounds, relative molecular mass 242.16. white methylcellulose or granular powder form. Odorless, odorless, water-absorbent, insoluble in organic solvents.

Chemical structure formula: C6H7(OH)2OCH2COONa Chemical formula: C8H11O5Na

Scope of application.

As a tackifier in the food industry, as a pharmaceutical medium in the pharmaceutical industry, as a binder and anti-re-settling agent in the daily chemical industry. It is used as a desizing agent and maintenance colloidal solution of garment printing paste in the industrial production of printing and dyeing factory. In petrochemical equipment, it can be used as a component of fracturing fluid in oil recovery plants.

Basic properties.

This product is the acetate of methylcellulose carboxymethyl ether, anionic cellulose ether, white or milk white methylcellulose powder or granules, relative density 0.5-0.7g/cm3, basically odorless, odorless, with water absorption. Easy to disperse in water into a transparent ribbon-like aqueous solution, insoluble in alcohol and other organic chemical soluble enzymes. 1% aqueous solution pH 6.5-8.5, when pH>10 or <5, the pulp's viscosity is obviously reduced, the best characteristics at pH=7. Smooth to heat, the viscosity rises rapidly below 20, the transformation is slower at 45, and the long-term heating above 80can make its colloidal solution transitive, and the viscosity and characteristics decrease significantly. Soluble in strong electrolytes, an aqueous solution is fully transparent; smooth in alkaline solution, easy to hydrolysis reaction when it meets acid, precipitation will appear when PH value is 2-3, and precipitation will also react when it meets multivalent metal salt.

Operation method.

Mix CMC with water immediately and configure it into a viscous adhesive, and then set aside. When equipped with CMC paste adhesive, first add a certain amount of neat water to the mixing master cylinder containing mixing equipment, and in the condition of opening the mixing equipment, splash CMC into the mixing master cylinder slowly and evenly, and keep mixing so that CMC and water are thoroughly combined, and CMC can be sufficiently melted. When melting CMC, it is often necessary to spread it evenly and mix it continuously to "better avoid the problem of clumping and agglomeration when CMC meets with water and reduces the amount of CMC melting" and to improve the melting rate of CMC. Generally speaking, the mixing time is much shorter than the time required for the complete melting of CMC, and the time required for both depends on the details.

The basis for defining the mixing time is.

When the CMC in the water dispersion, there is no significant large group of small pieces of objects, then you can stop mixing, so that CMC and water in the case of static infiltration, combined.

The basis for the complete melting of CMC is as follows.

CMC and water thoroughly bonded, there will be no solid-liquid separation between the two; mixing and paste is uniform, the surface layer is flat and smooth; mixing and paste color close to no color full transparency, paste in the absence of particulate matter. CMC is put into the mixing tank, and water mixing, to the CMC, completely melted, the time required in the middle of 10 ~ 20 hours.

Quality.

The key index values to evaluate the quality of CMC are substitution degree (DS) and purity. Generally, DS is different; CMC characteristics are also different; the degree of substitution expands, the solubility increases, and the aqueous solution's clarity and reliability are higher. It is reported that the clarity and transparency of CMC are most desirable when the degree of substitution is 0.7 to 1.2, and its solution viscosity is maximum at pH 6 to 9. In order to ensure its quality, in addition to the selection of the etherizing agent, must also take into account some elements that endanger the degree of substitution and purity, such as the amount of alkali and etherizing agent used in the middle of the correlation, etherification time, management system moisture content, temperature, pH, substance concentration and acidity, etc.

Common problems

This product is contraindicated with a strong alkali, strong acid, heavy metal ions (such as aluminum, zinc, mercury, silver, iron, etc.).

The allowable intake of this product is 0~25mg/kg-d.

National standard specification

GB/T12028-2006 Sodium carboxymethyl cellulose for detergents 684KB

GB1904-2005 Sodium carboxymethyl cellulose for food additive342KB

SY5093-92 Carboxymethyl Cellulose Acetate (CMC) for Drilling Fluids835KB

GB1904-2005 edible additive sodium carboxymethyl cellulose 1579KB

GB1904-1989 edible additive sodium carboxymethyl cellulose 213KB

QB/T2318-2007 Sodium carboxymethyl cellulose for toothpaste625KB


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